This indicates enough time-title reductions about urinary ratio do not all the way down blood circulation pressure

Despite numerous previous education reporting an association between blood pressure and you will the fresh urinary Na + /K + ratio there are several limitations to-be thought

At present there is conflicting evidence regarding the potential blood pressure lowering effects of a reduction in urinary Na + /K + excretion. The TAIM randomized control trial in co to jest jswipe hypertensive participants on a pharmacological intervention reported no significant difference in DBP between the control diet group and a low Na + /high K + diet group during a six month period . A multicenter study by Suppa et al. conducted in hypertensive participants reported a significant reduction in SBP following 4 weeks of modified low sodium high potassium salt intake compared to participants receiving a normal salt intake , yet all participants were receiving a beta blocker, which is not standard first line treatment for hypertension . In addition, a cross-sectional study, the Dallas heart study, which reported an increase in SBP for an increase in the urinary Na + /K + ratio is limited by the modest correlation the use of single morning urine sample . The PURE study reported a strong linear association between estimated Na + /K + ratio and SBP, that was maintained after covariate adjustment, with the greatest SBP observed with the highest estimated K + and lowest estimated K + excretion . Although we observed that a daily K + excretion of <1 g/day is associated with elevated SBP we observed no association between the urinary Na + /K + excretion ratio and SBP at screening or following DASH-dietary intervention in SS or SR participants. In conjunction with the study by Zanetti et al. , our data suggest high Na + and low K + excretion may increase the likelihood of having increased SBP. However, the lack of association between urinary Na + /K + ratio and SBP in our data do not support a urinary Na + /K + molar excretion ratio of 1:1 as a mechanism to lower blood pressure [16, 17].

The present day research has numerous pros: (1) The brand new Dashboard -Sodium trial was a carefully controlled feeding data and conformity was constantly monitored, (2) Brand new crossover framework getting Na + input desired participant’s in order to serve as their own manage and you can reduced inter-people variability, (3) 24-h ambulatory blood pressure tracks was drawn, (4) lack of new confounding aftereffects of antihypertensive mediations, and you will (5) 24-h urine sample collection.